7KBJ
Co-crystal structure of alpha glucosidase with compound 9
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | G, I | Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #1 | polymer | 184 | 20475.9 | 2 | UniProt (Q8BHN3) Pfam (PF13802) In PDB | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
2 | H, J | Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #2 | polymer | 107 | 12052.3 | 2 | UniProt (Q8BHN3) Pfam (PF13802) In PDB | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
3 | A, C | Neutral alpha-glucosidase AB Trypsin-cleaved Fragment #3 | polymer | 609 | 69898.7 | 2 | UniProt (Q8BHN3) Pfam (PF01055) Pfam (PF21365) In PDB | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
4 | B, D | Glucosidase 2 subunit beta | polymer | 134 | 14323.0 | 2 | UniProt (O08795) Pfam (PF12999) In PDB | Mus musculus (Mouse) | 80K-H protein,Glucosidase II subunit beta,Protein kinase C substrate 60.1 kDa protein heavy chain,PKCSH |
5 | G, A | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 5 | Chemie (PGE) | |||
6 | A, C, G, H, D | 1,2-ETHANEDIOL | non-polymer | 62.1 | 35 | Chemie (EDO) | |||
7 | A, G, B, C, J | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
8 | H, A | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 2 | Chemie (PG4) | |||
9 | A, C | (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-{[2-(2-{[2-nitro-4-(triazan-1-yl)phenyl]amino}ethoxy)ethyl]amino}cyclohexane-1,2,3,4-tetrol | non-polymer | 446.5 | 2 | Chemie (WAV) | |||
10 | A, C, B, I, J... | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 11 | Chemie (PEG) | |||
11 | B, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
12 | water | water | 18.0 | 1003 | Chemie (HOH) |
Sequence modifications
G, I: 33 - 185 (UniProt: Q8BHN3)
A, C: 370 - 966 (UniProt: Q8BHN3)
B, D: 15 - 117 (UniProt: O08795)
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Gly 3 | - | expression tag |
Ile 4 | - | expression tag |
Leu 5 | - | expression tag |
Pro 6 | - | expression tag |
Ser 7 | - | expression tag |
Pro 8 | - | expression tag |
Gly 9 | - | expression tag |
Met 10 | - | expression tag |
Pro 11 | - | expression tag |
Ala 12 | - | expression tag |
Leu 13 | - | expression tag |
Leu 14 | - | expression tag |
Ser 15 | - | expression tag |
Leu 16 | - | expression tag |
Val 17 | - | expression tag |
Ser 18 | - | expression tag |
Leu 19 | - | expression tag |
Leu 20 | - | expression tag |
Ser 21 | - | expression tag |
Val 22 | - | expression tag |
Leu 23 | - | expression tag |
Leu 24 | - | expression tag |
Met 25 | - | expression tag |
Gly 26 | - | expression tag |
Cys 27 | - | expression tag |
Val 28 | - | expression tag |
Ala 29 | - | expression tag |
Glu 30 | - | expression tag |
Thr 31 | - | expression tag |
Gly 32 | - | expression tag |
Asp 97 | Asn 97 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 967 | - | expression tag |
Ala 968 | - | expression tag |
Trp 969 | - | expression tag |
Ser 970 | - | expression tag |
His 971 | - | expression tag |
Pro 972 | - | expression tag |
Gln 973 | - | expression tag |
Phe 974 | - | expression tag |
Glu 975 | - | expression tag |
Lys 976 | - | expression tag |
Leu 977 | - | expression tag |
Glu 978 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
Gly -15 | - | expression tag |
Ile -14 | - | expression tag |
Leu -13 | - | expression tag |
Pro -12 | - | expression tag |
Ser -11 | - | expression tag |
Pro -10 | - | expression tag |
Gly -9 | - | expression tag |
Met -8 | - | expression tag |
Pro -7 | - | expression tag |
Ala -6 | - | expression tag |
Leu -5 | - | expression tag |
Leu -4 | - | expression tag |
Ser -3 | - | expression tag |
Leu -2 | - | expression tag |
Val -1 | - | expression tag |
Ser 0 | - | expression tag |
Leu 1 | - | expression tag |
Leu 2 | - | expression tag |
Ser 3 | - | expression tag |
Val 4 | - | expression tag |
Leu 5 | - | expression tag |
Leu 6 | - | expression tag |
Met 7 | - | expression tag |
Gly 8 | - | expression tag |
Cys 9 | - | expression tag |
Val 10 | - | expression tag |
Ala 11 | - | expression tag |
Glu 12 | - | expression tag |
Thr 13 | - | expression tag |
Gly 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 233499.9 | |
Non-Polymers* | Number of molecules | 67 |
Total formula weight | 6300.7 | |
All* | Total formula weight | 239800.6 |