7KAD
Co-crystal structure of alpha glucosidase with compound 6
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Isoform 2 of Neutral alpha-glucosidase AB | polymer | 977 | 110654.1 | 2 | UniProt (Q8BHN3-2) In PDB | Mus musculus (Mouse) | Alpha-glucosidase 2,Glucosidase II subunit alpha |
2 | B, D | Glucosidase 2 subunit beta | polymer | 554 | 62307.4 | 2 | UniProt (O08795) Pfam (PF12999) Pfam (PF13202) Pfam (PF07915) In PDB | Mus musculus (Mouse) | 80K-H protein,Glucosidase II subunit beta,Protein kinase C substrate 60.1 kDa protein heavy chain,PKCSH |
3 | A, C | (1S,2S,3R,4S,5S)-1-(hydroxymethyl)-5-[(6-{[2-nitro-4-(1H-1,2,3-triazol-1-yl)phenyl]amino}hexyl)amino]cyclohexane-1,2,3,4-tetrol | non-polymer | 480.5 | 2 | Chemie (W9Y) | |||
4 | C, A, B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 33 | Chemie (EDO) | |||
5 | A, C | TRIETHYLENE GLYCOL | non-polymer | 150.2 | 6 | Chemie (PGE) | |||
6 | A, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 13 | Chemie (PEG) | |||
7 | A, C | SULFATE ION | non-polymer | 96.1 | 13 | Chemie (SO4) | |||
8 | B, D | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
9 | C | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
10 | water | water | 18.0 | 453 | Chemie (HOH) |
Sequence modifications
A, C: 33 - 966 (UniProt: Q8BHN3-2)
B, D: 15 - 517 (UniProt: O08795)
PDB | External Database | Details |
---|---|---|
Met 2 | - | initiating methionine |
Gly 3 | - | expression tag |
Ile 4 | - | expression tag |
Leu 5 | - | expression tag |
Pro 6 | - | expression tag |
Ser 7 | - | expression tag |
Pro 8 | - | expression tag |
Gly 9 | - | expression tag |
Met 10 | - | expression tag |
Pro 11 | - | expression tag |
Ala 12 | - | expression tag |
Leu 13 | - | expression tag |
Leu 14 | - | expression tag |
Ser 15 | - | expression tag |
Leu 16 | - | expression tag |
Val 17 | - | expression tag |
Ser 18 | - | expression tag |
Leu 19 | - | expression tag |
Leu 20 | - | expression tag |
Ser 21 | - | expression tag |
Val 22 | - | expression tag |
Leu 23 | - | expression tag |
Leu 24 | - | expression tag |
Met 25 | - | expression tag |
Gly 26 | - | expression tag |
Cys 27 | - | expression tag |
Val 28 | - | expression tag |
Ala 29 | - | expression tag |
Glu 30 | - | expression tag |
Thr 31 | - | expression tag |
Gly 32 | - | expression tag |
Asp 97 | Asn 97 | engineered mutation |
Ser 967 | - | expression tag |
Ala 968 | - | expression tag |
Trp 969 | - | expression tag |
Ser 970 | - | expression tag |
His 971 | - | expression tag |
Pro 972 | - | expression tag |
Gln 973 | - | expression tag |
Phe 974 | - | expression tag |
Glu 975 | - | expression tag |
Lys 976 | - | expression tag |
Leu 977 | - | expression tag |
Glu 978 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -16 | - | initiating methionine |
Gly -15 | - | expression tag |
Ile -14 | - | expression tag |
Leu -13 | - | expression tag |
Pro -12 | - | expression tag |
Ser -11 | - | expression tag |
Pro -10 | - | expression tag |
Gly -9 | - | expression tag |
Met -8 | - | expression tag |
Pro -7 | - | expression tag |
Ala -6 | - | expression tag |
Leu -5 | - | expression tag |
Leu -4 | - | expression tag |
Ser -3 | - | expression tag |
Leu -2 | - | expression tag |
Val -1 | - | expression tag |
Ser 0 | - | expression tag |
Leu 1 | - | expression tag |
Leu 2 | - | expression tag |
Ser 3 | - | expression tag |
Val 4 | - | expression tag |
Leu 5 | - | expression tag |
Leu 6 | - | expression tag |
Met 7 | - | expression tag |
Gly 8 | - | expression tag |
Cys 9 | - | expression tag |
Val 10 | - | expression tag |
Ala 11 | - | expression tag |
Glu 12 | - | expression tag |
Thr 13 | - | expression tag |
Gly 14 | - | expression tag |
Ser 518 | - | expression tag |
Ala 519 | - | expression tag |
Trp 520 | - | expression tag |
Ser 521 | - | expression tag |
His 522 | - | expression tag |
Pro 523 | - | expression tag |
Gln 524 | - | expression tag |
Phe 525 | - | expression tag |
Glu 526 | - | expression tag |
Lys 527 | - | expression tag |
Leu 528 | - | expression tag |
Glu 529 | - | expression tag |
Thr 530 | - | expression tag |
Lys 531 | - | expression tag |
His 532 | - | expression tag |
His 533 | - | expression tag |
His 534 | - | expression tag |
His 535 | - | expression tag |
His 536 | - | expression tag |
His 537 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 345923.0 | |
Non-Polymers* | Number of molecules | 72 |
Total formula weight | 6893.2 | |
All* | Total formula weight | 352816.2 |