7K7L
Structure of a hit for G Protein Coupled Receptor Kinase 2 (GRK2) Inhibitor for the Potential Treatment of Heart Failure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Beta-adrenergic receptor kinase 1 | polymer | 640 | 74545.6 | 1 | UniProt (P25098) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) | Homo sapiens (Human) | Beta-ARK-1,G-protein coupled receptor kinase 2 |
| 2 | B (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 339 | 37285.7 | 1 | UniProt (P62873) Pfam (PF00400) | Homo sapiens (Human) | Transducin beta chain 1 |
| 3 | C (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 59 | 6519.5 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 4 | D (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 5 | E (A) | 3-benzyl-6-(1H-pyrazol-4-yl)quinazolin-4(3H)-one | non-polymer | 302.3 | 1 | Chemie (W4D) |
Sequence modifications
A: 30 - 668 (UniProt: P25098)
| PDB | External Database | Details |
|---|---|---|
| Ala 669 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 118350.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 326.6 | |
| All* | Total formula weight | 118677.5 |
