7K6Z
Carbonic Anhydrase IX mimic complexed with 4-(2-(3-(4-fluorophenyl)ureido)ethylsulfonamido)benzenesulfonamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Carbonic anhydrase 2 | polymer | 260 | 29200.9 | 1 | UniProt (P00918) Pfam (PF00194) In PDB | Homo sapiens (Human) | Carbonate dehydratase II,Carbonic anhydrase C,CAC,Carbonic anhydrase II,CA-II |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | A | 4-{[(2-{[(4-fluorophenyl)carbamoyl]amino}ethyl)sulfonyl]amino}benzene-1-sulfonamide | non-polymer | 416.4 | 1 | Chemie (VZD) | |||
5 | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 1 - 258 (UniProt: P00918)
PDB | External Database | Details |
---|---|---|
Ser 65 | Ala 65 | engineered mutation |
Gln 67 | Asn 67 | engineered mutation |
Thr 69 | Glu 69 | engineered mutation |
Leu 91 | Ile 91 | engineered mutation |
Val 131 | Phe 130 | engineered mutation |
Glu 170 | Lys 169 | engineered mutation |
Ala 204 | Leu 203 | engineered mutation |
Ser 259 | - | expression tag |
Phe 260 | - | expression tag |
Lys 261 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29200.9 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 560.0 | |
All* | Total formula weight | 29760.9 |