7K6Q

Active state Dot1 bound to the H4K16ac nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E	Histone H3.2	polymer	98	11562.6	2	UniProt (P84233) Pfam (PF00125) In PDB	Xenopus laevis (African clawed frog)
2	B, F	Histone H4	polymer	92	10403.2	2	UniProt (P62799) Pfam (PF15511) In PDB	Xenopus laevis (African clawed frog)
3	C, G	Histone H2A type 1	polymer	107	11694.6	2	UniProt (P06897) Pfam (PF00125) Pfam (PF16211) In PDB	Xenopus laevis (African clawed frog)
4	D, H	Histone H2B 1.1	polymer	93	10322.8	2	UniProt (P02281) Pfam (PF00125) In PDB	Xenopus laevis (African clawed frog)	H2B1.1
5	I	DNA (146-MER)	polymer	146	44824.6	1		synthetic construct
6	J	DNA (146-MER)	polymer	146	45304.9	1		synthetic construct
7	K	Histone-lysine N-methyltransferase, H3 lysine-79 specific	polymer	406	46686.1	1	UniProt (Q04089) Pfam (PF08123) In PDB	Saccharomyces cerevisiae (Baker's yeast)	Disrupter of telomere silencing protein 1,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4
8	L	Ubiquitin	polymer	76	8622.9	1	UniProt (P0CG48) Pfam (PF00240) In PDB	Homo sapiens (Human)
9	K	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)

Sequence modifications

A, E: 37 - 134 (UniProt: P84233)

PDB	External Database	Details
Met 79	Lys 80	engineered mutation
Ala 102	Gly 103	engineered mutation

C, G: 12 - 118 (UniProt: P06897)

PDB	External Database	Details
Arg 99	Gly 100	engineered mutation

D, H: 32 - 124 (UniProt: P02281)

PDB	External Database	Details
Thr 32	Ser 33	engineered mutation
Cys 120	Lys 121	engineered mutation

K: 176 - 580 (UniProt: Q04089)

PDB	External Database	Details
Met 581	-	expression tag

L: 1 - 76 (UniProt: P0CG48)

PDB	External Database	Details
Cys 76	Gly 76	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.