7K6P

Active state Dot1 bound to the unacetylated H4 nucleosome

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E (A, E)	Histone H3.2	polymer	98	11562.6	2	UniProt (P84233) Pfam (PF00125)	Xenopus laevis (African clawed frog)
2	B, F (B, F)	Histone H4	polymer	90	10176.0	2	UniProt (P62799) Pfam (PF15511)	Xenopus laevis (African clawed frog)
3	C, G (C, G)	Histone H2A type 1	polymer	107	11694.6	2	UniProt (P06897) Pfam (PF00125) Pfam (PF16211)	Xenopus laevis (African clawed frog)
4	D, H (D, H)	Histone H2B 1.1	polymer	93	10322.8	2	UniProt (P02281) Pfam (PF00125)	Xenopus laevis (African clawed frog)	H2B1.1
5	I (I)	DNA (146-MER)	polymer	146	44824.6	1		synthetic construct
6	J (J)	DNA (146-MER)	polymer	146	45304.9	1		synthetic construct
7	K (K)	Histone-lysine N-methyltransferase, H3 lysine-79 specific	polymer	406	46686.1	1	UniProt (Q04089) Pfam (PF08123)	Saccharomyces cerevisiae (Baker's yeast)	Disrupter of telomere silencing protein 1,Histone H3-K79 methyltransferase,H3-K79-HMTase,Lysine N-methyltransferase 4
8	L (L)	Ubiquitin	polymer	76	8622.9	1	UniProt (P0CG48) Pfam (PF00240)	Homo sapiens (Human)
9	M (K)	S-ADENOSYLMETHIONINE	non-polymer		398.4	1	Chemie (SAM)

Sequence modifications

A, E: 37 - 134 (UniProt: P84233)

PDB	External Database	Details
Met 79	Lys 80	engineered mutation
Ala 102	Gly 103	engineered mutation

C, G: 12 - 118 (UniProt: P06897)

PDB	External Database	Details
Arg 99	Gly 100	engineered mutation

D, H: 32 - 124 (UniProt: P02281)

PDB	External Database	Details
Thr 32	Ser 33	engineered mutation
Cys 120	Lys 121	engineered mutation

K: 176 - 580 (UniProt: Q04089)

PDB	External Database	Details
Met 581	-	expression tag

L: 1 - 76 (UniProt: P0CG48)

PDB	External Database	Details
Cys 76	Gly 76	engineered mutation

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.