7K6O
Crystal structure of PI3Kalpha inhibitor 10-5429
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | polymer | 946 | 109983.1 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (Human) | PtdIns-3-kinase subunit alpha,Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha,p110alpha,Phosphoinositide-3-kinase catalytic alpha polypeptide,Serine/threonine protein kinase PIK3CA |
2 | A | (3S)-3-[4-(2-aminopyrimidin-5-yl)-2-(morpholin-4-yl)-5,6-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-N-methylpyrrolidine-1-sulfonamide | non-polymer | 461.5 | 1 | Chemie (VY1) | |||
3 | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 105 - 1048 (UniProt: P42336)
PDB | External Database | Details |
---|---|---|
Gly 103 | - | expression tag |
Ser 104 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 109983.1 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 461.5 | |
All* | Total formula weight | 110444.6 |