7K4D
Cryo-EM structure of human TRPV6 in complex with (4- phenylcyclohexyl)piperazine inhibitor 3OG
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D (A, B, C, D) | Transient receptor potential cation channel subfamily V member 6 | polymer | 670 | 77021.8 | 4 | UniProt (Q9H1D0) Pfam (PF12796) Pfam (PF00023) Pfam (PF00520) | Homo sapiens (Human) | TrpV6,CaT-like,CaT-L,Calcium transport protein 1,CaT1,Epithelial calcium channel 2,ECaC2 |
2 | E, H, I, J, K (A, B, C, D) | 5-[(4-{trans-4-hydroxy-4-[3-(trifluoromethyl)phenyl]cyclohexyl}piperazin-1-yl)methyl]pyridin-2(1H)-one | non-polymer | 435.5 | 5 | Chemie (VUM) | |||
3 | F, G (A) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) |
Sequence modifications
A, B, C, D: 1 - 667 (UniProt: Q9H1D0)
PDB | External Database | Details |
---|---|---|
Val 668 | - | expression tag |
Pro 669 | - | expression tag |
Arg 670 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 308087.2 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 2257.6 | |
All* | Total formula weight | 310344.8 |