7K1N

CryoEM structure of inactivated-form DNA-PK (Complex V)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	DNA-dependent protein kinase catalytic subunit	polymer	4128	469673.2	1	UniProt (P78527) Pfam (PF20502) Pfam (PF08163) Pfam (PF19704) Pfam (PF02259) Pfam (PF00454) Pfam (PF02260) In PDB	Homo sapiens (Human)	DNA-PKcs,DNPK1,p460
2	B	X-ray repair cross-complementing protein 6	polymer	609	69945.0	1	UniProt (P12956) Pfam (PF02037) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) In PDB	Homo sapiens (Human)	5'-deoxyribose-5-phosphate lyase Ku70,5'-dRP lyase Ku70,70 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 1,ATP-dependent DNA helicase II 70 kDa subunit,CTC box-binding factor 75 kDa subunit,CTCBF,DNA repair protein XRCC6,Lupus Ku autoantigen protein p70,Ku70,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 6
3	C	X-ray repair cross-complementing protein 5	polymer	732	82812.4	1	UniProt (P13010) Pfam (PF03731) Pfam (PF02735) Pfam (PF03730) Pfam (PF08785) In PDB	Homo sapiens (Human)	86 kDa subunit of Ku antigen,ATP-dependent DNA helicase 2 subunit 2,ATP-dependent DNA helicase II 80 kDa subunit,CTC box-binding factor 85 kDa subunit,CTCBF,DNA repair protein XRCC5,Ku80,Ku86,Lupus Ku autoantigen protein p86,Nuclear factor IV,Thyroid-lupus autoantigen,TLAA,X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
4	D, F	DNA (5'-D(P*GP*CP*AP*TP*GP*CP*TP*CP*TP*AP*CP*TP*GP*CP*TP*TP*CP*GP*AP*TP*AP*TP*CP*G)-3')	polymer	24	7311.7	2		synthetic construct
5	E, G	DNA (5'-D(P*AP*AP*GP*CP*AP*GP*TP*AP*GP*AP*GP*CP*A)-3')	polymer	16	4956.2	2		synthetic construct

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	646966.6
All*	Total formula weight	646966.6

*Water molecules are not included.