7JYR
hALK in complex with 1-[(1R,2R)-1-(2,4-difluorophenyl)-2-[2-(5-methyl-1H-pyrazol-3-yl)-4-(trifluoromethyl)phenoxy]cyclopropyl]methanamine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ALK tyrosine kinase receptor | polymer | 322 | 36045.4 | 1 | UniProt (Q9UM73) Pfam (PF07714) | Homo sapiens (Human) | Anaplastic lymphoma kinase |
| 2 | B (A) | 4-{[(1R,2R)-2-(2,4-difluorophenyl)cyclopropyl]oxy}-3-(5-methyl-1H-pyrazol-3-yl)benzonitrile | non-polymer | 351.3 | 1 | Chemie (VTA) | |||
| 3 | C, D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 2 | Chemie (EDO) | |||
| 4 | E (A) | water | water | 18.0 | 79 | Chemie (HOH) |
Sequence modifications
A: 1090 - 1406 (UniProt: Q9UM73)
| PDB | External Database | Details |
|---|---|---|
| Gly 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| Met 1087 | - | expression tag |
| Gly 1088 | - | expression tag |
| Ser 1089 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36045.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 475.5 | |
| All* | Total formula weight | 36520.9 |
