7JXY

Structure of TTBK1 kinase domain in complex with Compound 18

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tau-tubulin kinase 1	polymer	332	37883.6	2	UniProt (Q5TCY1) Pfam (PF00069)	Homo sapiens (Human)	Brain-derived tau kinase
2	C, D (A, B)	(3S)-1-[1-(2-aminopyrimidin-4-yl)-1H-pyrazolo[4,3-c]pyridin-6-yl]-3-methylpent-1-yn-3-ol	non-polymer		308.3	2	Chemie (VSY)
3	E, F (A, B)	water	water		18.0	35	Chemie (HOH)

Sequence modifications

A, B: 15 - 343 (UniProt: Q5TCY1)

PDB	External Database	Details
Gly 12	-	expression tag
His 13	-	expression tag
Met 14	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75767.1
Non-Polymers*	Number of molecules	2
	Total formula weight	616.7
All*	Total formula weight	76383.8

*Water molecules are not included.