7JXX
Structure of TTBK1 kinase domain in complex with Compound 3
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tau-tubulin kinase 1 | polymer | 332 | 37883.6 | 1 | UniProt (Q5TCY1) Pfam (PF00069) | Homo sapiens (Human) | Brain-derived tau kinase |
| 2 | B (A) | 4-(2-amino-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-11-yl)-2-methylbut-3-yn-2-ol | non-polymer | 332.4 | 1 | Chemie (VP7) | |||
| 3 | C, D, E (A) | SODIUM ION | non-polymer | 23.0 | 3 | Chemie (NA) | |||
| 4 | F (A) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A: 15 - 343 (UniProt: Q5TCY1)
| PDB | External Database | Details |
|---|---|---|
| Gly 12 | - | expression tag |
| His 13 | - | expression tag |
| Met 14 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 37883.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 401.4 | |
| All* | Total formula weight | 38284.9 |
