7JXQ
EGFR kinase (T790M/V948R) in complex with allosteric inhibitor JBJ-09-063
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | D, A, B, C | Epidermal growth factor receptor | polymer | 331 | 37724.6 | 4 | UniProt (P00533) Pfam (PF07714) In PDB | Homo sapiens (Human) | Proto-oncogene c-ErbB-1,Receptor tyrosine-protein kinase erbB-1 |
2 | D, A, B, C | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
3 | D, A, B, C | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 4 | Chemie (ANP) | |||
4 | D, A, B, C | (2R)-2-(5-fluoro-2-hydroxyphenyl)-2-{6-[4-(1-methylpiperidin-4-yl)phenyl]-1-oxo-1,3-dihydro-2H-isoindol-2-yl}-N-(1,3-thiazol-2-yl)acetamide | non-polymer | 556.6 | 4 | Chemie (VNS) | |||
5 | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
D, A, B, C: 695 - 1022 (UniProt: P00533)
PDB | External Database | Details |
---|---|---|
Gly 692 | - | expression tag |
Ser 693 | - | expression tag |
Thr 694 | - | expression tag |
Met 790 | Thr 790 | engineered mutation |
Arg 948 | Val 948 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 150898.4 | |
Non-Polymers* | Number of molecules | 12 |
Total formula weight | 4348.6 | |
All* | Total formula weight | 155247.0 |