7JXH
HER2 in complex with JBJ-08-178-01
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (B, A, C, D, E...) | Receptor tyrosine-protein kinase erbB-2 | polymer | 326 | 36884.5 | 8 | UniProt (P04626) Pfam (PF07714) | Homo sapiens (Human) | Metastatic lymph node gene 19 protein,MLN 19,Proto-oncogene Neu,Proto-oncogene c-ErbB-2,Tyrosine kinase-type cell surface receptor HER2,p185erbB2 |
| 2 | I, J, K, L, M... (B, A, C, D, E...) | (2E)-N-[3-cyano-7-ethoxy-4-({3-methyl-4-[([1,2,4]triazolo[1,5-a]pyridin-7-yl)oxy]phenyl}amino)quinolin-6-yl]-4-(dimethylamino)but-2-enamide | non-polymer | 562.6 | 8 | Chemie (VOY) |
Sequence modifications
B, A, C, D, E, F, G, H: 703 - 1024 (UniProt: P04626)
| PDB | External Database | Details |
|---|---|---|
| Gly 699 | - | expression tag |
| Ser 700 | - | expression tag |
| Thr 701 | - | expression tag |
| Ser 702 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 295076.1 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4501.0 | |
| All* | Total formula weight | 299577.1 |
