7JWU
Crystal structure of human ALDH1A1 bound to compound (R)-28
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Retinal dehydrogenase 1 | polymer | 501 | 54897.6 | 1 | UniProt (V9HW83) Pfam (PF00171) UniProt (by SIFTS) (P00352) In PDB | Homo sapiens (Human) | RalDH1, ALDH-E1, ALHDII, Aldehyde dehydrogenase family 1 member A1, Aldehyde dehydrogenase, cytosolic |
| 2 | A | YTTERBIUM (III) ION | non-polymer | 173.0 | 2 | Chemie (YB) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | A | NICOTINAMIDE-ADENINE-DINUCLEOTIDE | non-polymer | 663.4 | 1 | Chemie (NAD) | |||
| 5 | A | 1-methyl-5-phenyl-6-{[(1R)-1-(pyridin-2-yl)ethyl]sulfanyl}-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one | non-polymer | 363.4 | 1 | Chemie (VMA) | |||
| 6 | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence modifications
A: 1 - 501 (UniProt: V9HW83)
| PDB | External Database | Details |
|---|---|---|
| Ser 121 | Asn 121 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 54897.6 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1443.8 | |
| All* | Total formula weight | 56341.4 |
