7JVQ
Cryo-EM structure of apomorphine-bound dopamine receptor 1 in complex with Gs protein
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | R | D(1A) dopamine receptor | polymer | 502 | 55668.7 | 1 | UniProt (P21728) Pfam (PF00001) In PDB | Homo sapiens (Human) | Dopamine D1 receptor |
2 | A | Engineered mini-Gi protein alpha sub-unit | polymer | 246 | 29048.9 | 1 | Pfam (PF00503) UniProt (by SIFTS) (P63092) In PDB | Homo sapiens (human) | |
3 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 354 | 39077.7 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
4 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7432.6 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
5 | N | Nanobody35 | polymer | 135 | 14845.5 | 1 | synthetic construct | ||
6 | R | (6aR)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol | non-polymer | 267.3 | 1 | Chemie (OR9) | |||
7 | R | CHOLESTEROL | non-polymer | 386.7 | 5 | Chemie (CLR) | |||
8 | R | PALMITIC ACID | non-polymer | 256.4 | 3 | Chemie (PLM) |
Sequence modifications
R: 1 - 446 (UniProt: P21728)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Asp -47 | - | expression tag |
Tyr -46 | - | expression tag |
Lys -45 | - | expression tag |
Asp -44 | - | expression tag |
Asp -43 | - | expression tag |
Asp -42 | - | expression tag |
Asp -41 | - | expression tag |
Val -40 | - | expression tag |
Asp -39 | - | expression tag |
Met -38 | - | expression tag |
Gly -37 | - | expression tag |
Gln -36 | - | expression tag |
Pro -35 | - | expression tag |
Gly -34 | - | expression tag |
Asn -33 | - | expression tag |
Gly -32 | - | expression tag |
Ser -31 | - | expression tag |
Ala -30 | - | expression tag |
Phe -29 | - | expression tag |
Leu -28 | - | expression tag |
Leu -27 | - | expression tag |
Ala -26 | - | expression tag |
Pro -25 | - | expression tag |
Asn -24 | - | expression tag |
Gly -23 | - | expression tag |
Ser -22 | - | expression tag |
His -21 | - | expression tag |
Ala -20 | - | expression tag |
Pro -19 | - | expression tag |
Asp -18 | - | expression tag |
His -17 | - | expression tag |
Asp -16 | - | expression tag |
Val -15 | - | expression tag |
Thr -14 | - | expression tag |
Gln -13 | - | expression tag |
Gln -12 | - | expression tag |
Arg -11 | - | expression tag |
Asp -10 | - | expression tag |
Glu -9 | - | expression tag |
Glu -8 | - | expression tag |
Asn -7 | - | expression tag |
Leu -6 | - | expression tag |
Tyr -5 | - | expression tag |
Phe -4 | - | expression tag |
Gln -3 | - | expression tag |
Gly -2 | - | expression tag |
Ala -1 | - | expression tag |
Ser 0 | - | expression tag |
His 447 | - | expression tag |
His 448 | - | expression tag |
His 449 | - | expression tag |
His 450 | - | expression tag |
His 451 | - | expression tag |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
Met -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
Gly 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 146073.4 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2969.9 | |
All* | Total formula weight | 149043.3 |