7JV5
Cryo-EM structure of SKF-81297-bound dopamine receptor 1 in complex with Gs protein
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (R) | D(1A) dopamine receptor | polymer | 502 | 55668.7 | 1 | UniProt (P21728) Pfam (PF00001) | Homo sapiens (Human) | Dopamine D1 receptor |
| 2 | B (A) | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | polymer | 393 | 45624.4 | 1 | UniProt (P63092) Pfam (PF00503) | Homo sapiens (Human) | Adenylate cyclase-stimulating G alpha protein |
| 3 | C (B) | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 354 | 39077.7 | 1 | UniProt (P62873) Pfam (PF25391) | Homo sapiens (Human) | Transducin beta chain 1 |
| 4 | D (G) | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 67 | 7432.6 | 1 | UniProt (P59768) Pfam (PF00631) | Homo sapiens (Human) | G gamma-I |
| 5 | E (N) | Nanobody 35 | polymer | 135 | 14845.5 | 1 | synthetic construct | ||
| 6 | F (R) | (1R)-6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol | non-polymer | 289.8 | 1 | Chemie (SK0) PubChem (1218) PubChem (6603994) PubChem (12668019) | |||
| 7 | G, H, I, J, K... (R) | CHOLESTEROL | non-polymer | 386.7 | 6 | Chemie (CLR) PubChem (304) PubChem (191463) PubChem (368063) PubChem (369319) PubChem (638019) PubChem (1549081) PubChem (1553803) PubChem (5283629) PubChem (5284644) PubChem (5315842) PubChem (6419195) PubChem (6994560) PubChem (7055705) PubChem (7055706) PubChem (7059398) PubChem (7059400) PubChem (7059635) PubChem (7103033) PubChem (7182477) PubChem (7182478) PubChem (9909206) PubChem (10045721) PubChem (71168115) PubChem (10134774) PubChem (10293553) PubChem (71173031) PubChem (11003580) PubChem (11025495) PubChem (11058155) PubChem (11463329) PubChem (11868624) PubChem (11868625) PubChem (11869366) PubChem (11869367) PubChem (11869368) PubChem (11869369) PubChem (12120344) PubChem (12156156) PubChem (12303135) PubChem (12303148) PubChem (12303156) PubChem (12303159) PubChem (12303160) PubChem (16219173) PubChem (16758052) PubChem (40477506) PubChem (40557614) PubChem (42579431) PubChem (42579432) PubChem (176980071) PubChem (45044259) PubChem (18640088) PubChem (1715243) PubChem (1715244) PubChem (23423981) PubChem (49853509) PubChem (44654663) PubChem (46937002) PubChem (59274407) PubChem (50990013) PubChem (68311425) PubChem (68311398) PubChem (143173313) PubChem (177156123) PubChem (5997) PubChem (1551269) PubChem (90070115) PubChem (52934537) PubChem (117965027) PubChem (6432564) PubChem (6710666) PubChem (124146240) PubChem (56621683) PubChem (7059399) PubChem (124897607) PubChem (124896959) PubChem (10861996) PubChem (132837164) PubChem (11834483) PubChem (11888915) PubChem (11888914) PubChem (57915018) PubChem (57939063) PubChem (138967089) PubChem (58428240) PubChem (58445498) PubChem (139566851) PubChem (58663286) PubChem (15939944) PubChem (59450329) PubChem (59628412) PubChem (171828367) PubChem (173516975) PubChem (59965215) PubChem (71234641) PubChem (59993755) PubChem (60001463) PubChem (66634651) PubChem (68055877) PubChem (68166463) PubChem (68315613) PubChem (70795838) PubChem (70797612) PubChem (70954610) PubChem (70957185) PubChem (71463909) PubChem (89951918) PubChem (90224410) PubChem (91298236) PubChem (101624109) PubChem (124225449) PubChem (124429284) PubChem (124909223) PubChem (124909224) PubChem (124909225) PubChem (130459183) PubChem (131992107) PubChem (139568882) PubChem (142983773) PubChem (144054483) PubChem (144209461) PubChem (144331236) PubChem (144808354) PubChem (145053568) PubChem (145157652) PubChem (145215073) PubChem (145230478) PubChem (146320991) PubChem (147857230) PubChem (154993519) PubChem (158603858) PubChem (162906452) PubChem (162906453) PubChem (162906454) PubChem (162906455) PubChem (162906456) PubChem (162906457) PubChem (163255768) PubChem (163389210) PubChem (164665303) PubChem (166553771) PubChem (166712004) PubChem (170116175) PubChem (171764280) PubChem (171817101) PubChem (171817104) PubChem (174285573) | |||
| 8 | M, N, O, P, Q... (R) | PALMITIC ACID | non-polymer | 256.4 | 6 | Chemie (PLM) |
Sequence modifications
R: 1 - 446 (UniProt: P21728)
A: 2 - 394 (UniProt: P63092)
B: 2 - 340 (UniProt: P62873)
| PDB | External Database | Details |
|---|---|---|
| Asp -47 | - | expression tag |
| Tyr -46 | - | expression tag |
| Lys -45 | - | expression tag |
| Asp -44 | - | expression tag |
| Asp -43 | - | expression tag |
| Asp -42 | - | expression tag |
| Asp -41 | - | expression tag |
| Val -40 | - | expression tag |
| Asp -39 | - | expression tag |
| Met -38 | - | expression tag |
| Gly -37 | - | expression tag |
| Gln -36 | - | expression tag |
| Pro -35 | - | expression tag |
| Gly -34 | - | expression tag |
| Asn -33 | - | expression tag |
| Gly -32 | - | expression tag |
| Ser -31 | - | expression tag |
| Ala -30 | - | expression tag |
| Phe -29 | - | expression tag |
| Leu -28 | - | expression tag |
| Leu -27 | - | expression tag |
| Ala -26 | - | expression tag |
| Pro -25 | - | expression tag |
| Asn -24 | - | expression tag |
| Gly -23 | - | expression tag |
| Ser -22 | - | expression tag |
| His -21 | - | expression tag |
| Ala -20 | - | expression tag |
| Pro -19 | - | expression tag |
| Asp -18 | - | expression tag |
| His -17 | - | expression tag |
| Asp -16 | - | expression tag |
| Val -15 | - | expression tag |
| Thr -14 | - | expression tag |
| Gln -13 | - | expression tag |
| Gln -12 | - | expression tag |
| Arg -11 | - | expression tag |
| Asp -10 | - | expression tag |
| Glu -9 | - | expression tag |
| Glu -8 | - | expression tag |
| Asn -7 | - | expression tag |
| Leu -6 | - | expression tag |
| Tyr -5 | - | expression tag |
| Phe -4 | - | expression tag |
| Gln -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ala -1 | - | expression tag |
| Ser 0 | - | expression tag |
| His 447 | - | expression tag |
| His 448 | - | expression tag |
| His 449 | - | expression tag |
| His 450 | - | expression tag |
| His 451 | - | expression tag |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 226 | Gly 226 | conflict |
| Ser 366 | Ala 366 | conflict |
| PDB | External Database | Details |
|---|---|---|
| His -12 | - | expression tag |
| His -11 | - | expression tag |
| His -10 | - | expression tag |
| His -9 | - | expression tag |
| His -8 | - | expression tag |
| His -7 | - | expression tag |
| His -6 | - | expression tag |
| His -5 | - | expression tag |
| Met -4 | - | expression tag |
| Gly -3 | - | expression tag |
| Ser -2 | - | expression tag |
| Leu -1 | - | expression tag |
| Leu 0 | - | expression tag |
| Gln 1 | - | expression tag |
| Gly 341 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 162648.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 4148.2 | |
| All* | Total formula weight | 166797.1 |
