7JU6
Structure of RET protein tyrosine kinase in complex with selpercatinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Proto-oncogene tyrosine-protein kinase receptor Ret | polymer | 314 | 35708.2 | 2 | UniProt (P07949) Pfam (PF07714) | Homo sapiens (Human) | Cadherin family member 12,Proto-oncogene c-Ret |
| 2 | C, H (A, B) | Selpercatinib | non-polymer | 525.6 | 2 | Chemie (Q6G) | |||
| 3 | D, E, F, G, I (A, B) | FORMIC ACID | non-polymer | 46.0 | 5 | Chemie (FMT) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 146 | Chemie (HOH) |
Sequence modifications
A, B: 705 - 1013 (UniProt: P07949)
| PDB | External Database | Details |
|---|---|---|
| Gly 700 | - | expression tag |
| Pro 701 | - | expression tag |
| Leu 702 | - | expression tag |
| Ser 703 | - | expression tag |
| Leu 704 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71416.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1281.3 | |
| All* | Total formula weight | 72697.8 |
