7JTG

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-43

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RM11-43 Fab heavy chain	polymer	233	24301.4	1		Macaca mulatta
2	B (B)	RM11-43 Fab light chain	polymer	214	23254.7	1		Macaca mulatta
3	C (E)	Envelope glycoprotein E2	polymer	189	20707.4	1	UniProt (B9V0E2) Pfam (PF01560)	Recombinant Hepatitis C virus HK6a/JFH-1
4	D (G)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
5	E (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
6	F, G, H (A, B, E)	water	water		18.0	46	Chemie (HOH)

Sequence modifications

E: 412 - 481 (UniProt: B9V0E2)

PDB	External Database	Details
Asp 448	Asn 448	engineered mutation

E: 486 - 591 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 482	-	linker
Ser 483	-	linker
Ser 484	-	linker
Gly 485	-	linker

E: 594 - 596 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 592	-	linker
Gly 593	-	linker

E: 598 - 645 (UniProt: B9V0E2)

PDB	External Database	Details
Gly 597	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	68263.6
Branched	Number of molecules	1
	Total formula weight	424.4
Non-Polymers*	Number of molecules	1
	Total formula weight	221.2
All*	Total formula weight	68909.2

*Water molecules are not included.