7JTG
Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody RM11-43
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | RM11-43 Fab heavy chain | polymer | 233 | 24301.4 | 1 | Macaca mulatta | ||
2 | B | RM11-43 Fab light chain | polymer | 214 | 23254.7 | 1 | Macaca mulatta | ||
3 | E | Envelope glycoprotein E2 | polymer | 189 | 20707.4 | 1 | UniProt (B9V0E2) Pfam (PF01560) In PDB | Recombinant Hepatitis C virus HK6a/JFH-1 | |
4 | G | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
5 | E | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
6 | water | water | 18.0 | 46 | Chemie (HOH) |
Sequence modifications
E: 412 - 481 (UniProt: B9V0E2)
E: 486 - 591 (UniProt: B9V0E2)
E: 594 - 596 (UniProt: B9V0E2)
E: 598 - 645 (UniProt: B9V0E2)
PDB | External Database | Details |
---|---|---|
Asp 448 | Asn 448 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Gly 482 | - | linker |
Ser 483 | - | linker |
Ser 484 | - | linker |
Gly 485 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 592 | - | linker |
Gly 593 | - | linker |
PDB | External Database | Details |
---|---|---|
Gly 597 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 68263.6 | |
Branched | Number of molecules | 1 |
Total formula weight | 424.4 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 221.2 | |
All* | Total formula weight | 68909.2 |