7JRA
HUMAN TNF-ALPHA IN COMPLEX WITH 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Tumor necrosis factor | polymer | 160 | 17697.1 | 3 | UniProt (P01375) Pfam (PF00229) | Homo sapiens (Human) | Cachectin,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a |
| 2 | D (B) | 2-[5-(3-chloro-4-{[(1R)-1-(2-fluorophenyl)ethyl]amino}quinolin-6-yl)pyrimidin-2-yl]propan-2-ol | non-polymer | 436.9 | 1 | Chemie (VGY) | |||
| 3 | E (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | F, G, H (A, B, C) | water | water | 18.0 | 170 | Chemie (HOH) |
Sequence modifications
A, B, C: 77 - 233 (UniProt: P01375)
| PDB | External Database | Details |
|---|---|---|
| Gly 74 | - | expression tag |
| His 75 | - | expression tag |
| Met 76 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 53091.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 529.0 | |
| All* | Total formula weight | 53620.2 |
