7JR6
H-PDGS complexed with a 2-phenylimidazo[1,2-a]pyridine-6-carboxamide inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Hematopoietic prostaglandin D synthase | polymer | 200 | 23427.9 | 2 | UniProt (O60760) Pfam (PF02798) Pfam (PF14497) | Homo sapiens (Human) | H-PGDS,GST class-sigma,Glutathione S-transferase,Glutathione-dependent PGD synthase,Glutathione-requiring prostaglandin D synthase,Prostaglandin-H2 D-isomerase |
| 2 | C, H (A, B) | GLUTATHIONE | non-polymer | 307.3 | 2 | Chemie (GSH) | |||
| 3 | D, I (A, B) | 1-(3-fluorophenyl)-N-[trans-4-(2-hydroxypropan-2-yl)cyclohexyl]-1,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxamide | non-polymer | 400.5 | 2 | Chemie (VH4) | |||
| 4 | E, J (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 5 | F, G (A) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 6 | K, L (A, B) | water | water | 18.0 | 369 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 199 (UniProt: O60760)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 46855.8 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 1510.2 | |
| All* | Total formula weight | 48366.0 |
