7JQK
Crystal structure of the R64A mutant of Bauhinia Bauhinioides Kallikrein Inhibitor complexed with Human Kallikrein 4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (E) | Kallikrein-4 | polymer | 223 | 23942.0 | 1 | UniProt (Q9Y5K2) Pfam (PF00089) | Homo sapiens (Human) | Enamel matrix serine proteinase 1,Kallikrein-like protein 1,KLK-L1,Prostase,Serine protease 17 |
| 2 | B (I) | Kunitz-type inihibitor | polymer | 165 | 17997.4 | 1 | UniProt (Q6VEQ7) Pfam (PF00197) UniProt (by SIFTS) (P83052) | Bauhinia bauhinioides | |
| 3 | C, D (E) | NONAETHYLENE GLYCOL | non-polymer | 414.5 | 2 | Chemie (2PE) | |||
| 4 | E, F (E, I) | CADMIUM ION | non-polymer | 112.4 | 2 | Chemie (CD) | |||
| 5 | G, H (I) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 6 | I, J (E, I) | water | water | 18.0 | 644 | Chemie (HOH) |
Sequence modifications
E: 16 - 244 (UniProt: Q9Y5K2)
I: 1 - 165 (UniProt: Q6VEQ7)
| PDB | External Database | Details |
|---|---|---|
| Gln 186 | His 197 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ala 64 | Arg 82 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 41939.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1124.7 | |
| All* | Total formula weight | 43064.1 |
