7JOU
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 1 (ROCK1) IN COMPLEX WITH A PHENYLPYRAZOLE AMIDE INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Rho-associated protein kinase 1 | polymer | 413 | 47812.1 | 1 | UniProt (Q13464) Pfam (PF00069) | Homo sapiens (Human) | Renal carcinoma antigen NY-REN-35,Rho-associated,coiled-coil-containing protein kinase 1,coiled-coil-containing protein kinase I,ROCK-I,p160 ROCK-1,p160ROCK |
| 2 | B (A) | N-[(1S)-2-hydroxy-1-phenylethyl]-3-methoxy-4-(1H-pyrazol-4-yl)benzamide | non-polymer | 337.4 | 1 | Chemie (VFS) | |||
| 3 | C (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 6 - 415 (UniProt: Q13464)
| PDB | External Database | Details |
|---|---|---|
| Gly 3 | - | expression tag |
| His 4 | - | expression tag |
| Met 5 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 47812.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 337.4 | |
| All* | Total formula weight | 48149.4 |
