7JNT
CRYSTAL STRUCTURE OF RHO-ASSOCIATED PROTEIN KINASE 2 (ROCK2) IN COMPLEX WITH A POTENT AND SELECTIVE DUAL ROCK INHIBITOR
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Rho-associated protein kinase 2 | polymer | 399 | 45700.9 | 8 | UniProt (O75116) Pfam (PF00069) | Homo sapiens (Human) | Rho kinase 2,Rho-associated,coiled-coil-containing protein kinase 2,coiled-coil-containing protein kinase II,ROCK-II,p164 ROCK-2 |
| 2 | I, K, M, O, Q... (A, B, C, D, E...) | N-[(3-methoxyphenyl)methyl]-5H-[1]benzopyrano[3,4-c]pyridine-8-carboxamide | non-polymer | 346.4 | 8 | Chemie (VFA) | |||
| 3 | J, P, R, U, W... (A, D, E, F, G...) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 6 | Chemie (MES) | |||
| 4 | L, N, T (B, C, F) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 5 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 273 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 365607.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 4048.8 | |
| All* | Total formula weight | 369656.1 |
