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7JLG

Human PrimPol extending from the erroneous primer base A opposite the 8-oxoguanine lesion

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, B)
DNA-directed primase/polymerase proteinpolymer35441038.52UniProt (Q96LW4)
Pfam (PF01896)
Homo sapiens (Human)hPrimpol1,Coiled-coil domain-containing protein 111
2B, E
(C, G)
DNA (5'-D(P*AP*TP*(8OG)P*CP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*C)-3')polymer175053.32synthetic construct
3C, F
(D, H)
DNA (5'-D(P*GP*TP*GP*TP*GP*GP*TP*AP*GP*GP*A)-3')polymer134127.72synthetic construct
4G, J
(A, B)
2'-DEOXYADENOSINE 5'-TRIPHOSPHATEnon-polymer491.22Chemie (DTP)
5H, I, K, L
(A, B)
CALCIUM IONnon-polymer40.14Chemie (CA)
6M
(B)
DI(HYDROXYETHYL)ETHERnon-polymer106.11Chemie (PEG)
7N, O
(B)
GLYCEROLnon-polymer92.12Chemie (GOL)
8P, Q, R, S, T
(A, C, B, G, H)
waterwater18.0131Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight100438.9
Non-Polymers*Number of molecules9
Total formula weight1433.0
All*Total formula weight101871.9
*Water molecules are not included.

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PDB entries from 2025-12-03

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