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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

7IN7

Crystal structure of A2A in complex with 5 mM ZM241385 for 3h

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)		Adenosine receptor A2a/Soluble cytochrome b562/Adenosine receptor A2a chimerapolymer43348012.71UniProt (P29274)
UniProt (P0ABE7)		Homo sapiens (human)Cytochrome b-562
2B
(A)		SODIUM IONnon-polymer23.01Chemie (NA)
PubChem (923)
3C, D, E
(A)		CHOLESTEROLnon-polymer386.73Chemie (CLR)
PubChem (16219173)
PubChem (16758052)
PubChem (176980071)
PubChem (18640088)
PubChem (1715243)
PubChem (1715244)
PubChem (23423981)
PubChem (44654663)
PubChem (46937002)
PubChem (40477506)
PubChem (40557614)
PubChem (42579431)
PubChem (42579432)
PubChem (59274407)
PubChem (45044259)
PubChem (68311425)
PubChem (68311398)
PubChem (143173313)
PubChem (177156123)
PubChem (5997)
PubChem (1551269)
PubChem (90070115)
PubChem (49853509)
PubChem (50990013)
PubChem (117965027)
PubChem (6432564)
PubChem (6710666)
PubChem (124146240)
PubChem (52934537)
PubChem (7059399)
PubChem (124897607)
PubChem (124896959)
PubChem (10861996)
PubChem (56621683)
PubChem (132837164)
PubChem (11834483)
PubChem (11888915)
PubChem (11888914)
PubChem (138967089)
PubChem (139566851)
PubChem (15939944)
PubChem (57915018)
PubChem (57939063)
PubChem (58428240)
PubChem (58445498)
PubChem (58663286)
PubChem (171828367)
PubChem (173516975)
PubChem (59450329)
PubChem (59628412)
PubChem (59965215)
PubChem (71234641)
PubChem (59993755)
PubChem (60001463)
PubChem (66634651)
PubChem (68055877)
PubChem (68166463)
PubChem (68315613)
PubChem (70795838)
PubChem (70797612)
PubChem (70954610)
PubChem (70957185)
PubChem (71463909)
PubChem (89951918)
PubChem (90224410)
PubChem (91298236)
PubChem (101624109)
PubChem (304)
PubChem (124225449)
PubChem (191463)
PubChem (368063)
PubChem (369319)
PubChem (124429284)
PubChem (638019)
PubChem (124909223)
PubChem (124909224)
PubChem (124909225)
PubChem (1549081)
PubChem (1553803)
PubChem (5283629)
PubChem (5284644)
PubChem (5315842)
PubChem (6419195)
PubChem (6994560)
PubChem (7055705)
PubChem (7055706)
PubChem (7059398)
PubChem (7059400)
PubChem (7059635)
PubChem (7103033)
PubChem (7182477)
PubChem (7182478)
PubChem (9909206)
PubChem (10045721)
PubChem (71168115)
PubChem (10134774)
PubChem (10293553)
PubChem (71173031)
PubChem (11003580)
PubChem (11025495)
PubChem (11058155)
PubChem (11463329)
PubChem (11868624)
PubChem (11868625)
PubChem (11869366)
PubChem (11869367)
PubChem (11869368)
PubChem (11869369)
PubChem (130459183)
PubChem (12120344)
PubChem (12156156)
PubChem (12303135)
PubChem (12303148)
PubChem (12303156)
PubChem (12303159)
PubChem (12303160)
PubChem (131992107)
PubChem (139568882)
PubChem (142983773)
PubChem (144054483)
PubChem (144209461)
PubChem (144331236)
PubChem (144808354)
PubChem (145053568)
PubChem (145157652)
PubChem (145215073)
PubChem (145230478)
PubChem (146320991)
PubChem (147857230)
PubChem (154993519)
PubChem (158603858)
PubChem (162906452)
PubChem (162906453)
PubChem (162906454)
PubChem (162906455)
PubChem (162906456)
PubChem (162906457)
PubChem (163255768)
PubChem (163389210)
PubChem (164665303)
PubChem (166553771)
PubChem (166712004)
PubChem (170116175)
PubChem (171764280)
PubChem (171817101)
PubChem (171817104)
PubChem (174285573)
4AA, F, G, H, I...
(A)		OLEIC ACIDnon-polymer282.522Chemie (OLA)
PubChem (965)
PubChem (445639)
PubChem (637517)
5BA, CA, DA, EA, FA...
(A)		(2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoatenon-polymer356.57Chemie (OLC)
PubChem (25021708)
PubChem (54294270)
PubChem (46840179)
PubChem (33022)
PubChem (54294271)
PubChem (5283468)
PubChem (5364833)
PubChem (11451146)
PubChem (12178130)
6IA
(A)		waterwater18.041Chemie (HOH)
Sequence modifications
A: 2 - 208 (UniProt: P29274)
PDBExternal DatabaseDetails
Asp -8-expression tag
Tyr -7-expression tag
Lys -6-expression tag
Asp -5-expression tag
Asp -4-expression tag
Asp -3-expression tag
Asp -2-expression tag
Gly -1-expression tag
Ala 0-expression tag
Pro 1-expression tag
Leu 54Ala 54engineered mutation
Ala 88Thr 88engineered mutation
Ala 107Arg 107engineered mutation
Ala 122Lys 122engineered mutation
Ala 154Asn 154engineered mutation
Ala 202Leu 202engineered mutation
A: 1001 - 1101 (UniProt: P0ABE7)
PDBExternal DatabaseDetails
Trp 1007Met 29conflict
Ile 1102-linker
Gln 1103-linker
Lys 1104-linker
Tyr 1105-linker
Leu 1106-linker
A: 219 - 317 (UniProt: P29274)
PDBExternal DatabaseDetails
Ala 235Leu 235engineered mutation
Ala 239Val 239engineered mutation
Ala 318-expression tag
His 319-expression tag
His 320-expression tag
His 321-expression tag
His 322-expression tag
His 323-expression tag
His 324-expression tag
His 325-expression tag
His 326-expression tag
His 327-expression tag
His 328-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight48012.7
Non-Polymers*Number of molecules33
Total formula weight9892.9
All*Total formula weight57905.6
*Water molecules are not included.

253795

PDB entries from 2026-05-20

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