7IAW
Crystal structure of Zika NS2B-NS3 protease in complex with fragment EOS102818 from ECBL-96
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | NS2B co-factor | polymer | 53 | 5865.4 | 2 | UniProt (A0A142IX72) Pfam (PF01002) | Zika virus | |
| 2 | B, D (B, D) | NS3 protease | polymer | 176 | 18877.4 | 2 | UniProt (A0A142IX72) Pfam (PF00949) | Zika virus | |
| 3 | E, F (D) | 1-(quinolin-3-yl)methanamine | non-polymer | 158.2 | 2 | Chemie (WQY) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
A, C: 45 - 96 (UniProt: A0A142IX72)
B, D: 2 - 177 (UniProt: A0A142IX72)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Ser 143 | Cys 1639 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 49485.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 316.4 | |
| All* | Total formula weight | 49802.0 |
