7I9C

Crystal Structure of 30 bound to the PH domain of Btk

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, F, J)	Tyrosine-protein kinase BTK	polymer	169	19966.9	4	UniProt (Q06187) Pfam (PF00169) Pfam (PF00779)	Homo sapiens (human)	Agammaglobulinemia tyrosine kinase,ATK,B-cell progenitor kinase,BPK,Bruton tyrosine kinase
2	E, H, K, N (A, B, F, J)	(6R)-6-(3-bromothiophen-2-yl)-4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid	non-polymer		327.2	4	Chemie (A1B6L)	Homo sapiens
3	F, J, L, P (A, B, F, J)	ZINC ION	non-polymer		65.4	4	Chemie (ZN) PubChem (32051)
4	G, I, M, O (A, B, F, J)	MAGNESIUM ION	non-polymer		24.3	4	Chemie (MG) PubChem (888)
5	Q, R, S, T (A, B, F, J)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A, B, F, J: 2 - 170 (UniProt: Q06187)

PDB	External Database	Details
Ser 145	Cys 145	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	79867.8
Non-Polymers*	Number of molecules	12
	Total formula weight	1667.6
All*	Total formula weight	81535.4

*Water molecules are not included.