7I2S
Group deposition for crystallographic fragment screening of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 -- Crystal structure of the NS5 RNA-dependent RNA polymerase from Dengue virus serotype 2 in complex with Z31721798 (DNV2_NS5A-x0771)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NS5 RNA-dependent RNA polymerase | polymer | 637 | 73890.0 | 1 | UniProt (Q91H74) Pfam (PF00972) Pfam (PF20483) | dengue virus type 2 | |
| 2 | B, C (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 4 | E, F, G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 3 | Chemie (DMS) | |||
| 5 | H, K (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) | |||
| 6 | I, J (A) | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 7 | L (A) | 3-cyclohexyl-1-(morpholin-4-yl)propan-1-one | non-polymer | 225.3 | 1 | Chemie (NW4) | |||
| 8 | M (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 9 | N (A) | water | water | 18.0 | 419 | Chemie (HOH) |
Sequence modifications
A: 266 - 900 (UniProt: Q91H74)
| PDB | External Database | Details |
|---|---|---|
| Gly 264 | - | expression tag |
| Pro 265 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 73890.0 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1223.4 | |
| All* | Total formula weight | 75113.4 |
