7H67
THE 1.35 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH 2-[(3,5-dimethyl-1-benzothiophen-2-yl)-phenylmethyl]-3-hydroxy-4-methyl-4-phenylcyclobut-2-en-1-one
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Chymase | polymer | 226 | 25032.9 | 1 | UniProt (P23946) Pfam (PF00089) | Homo sapiens (human) | Alpha-chymase,Mast cell protease I |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | (4S)-2-[(R)-(3,5-dimethyl-1-benzothiophen-2-yl)(phenyl)methyl]-3-hydroxy-4-methyl-4-phenylcyclobut-2-en-1-one | non-polymer | 424.6 | 1 | Chemie (A1AO3) | |||
| 4 | D (A) | water | water | 18.0 | 423 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P23946)
| PDB | External Database | Details |
|---|---|---|
| Ser 22 | Cys 28 | engineered mutation |
| Lys 127 | Phe 135 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 25032.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 490.0 | |
| All* | Total formula weight | 25522.9 |
