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7GQU

Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ABifunctional 3'-5' exonuclease/ATP-dependent helicase WRNpolymer43950064.71UniProt (Q14191)
Pfam (PF00270)
Pfam (PF00271)
Pfam (PF16124)
In PDB
Homo sapiens (human)
2AZINC IONnon-polymer65.41Chemie (ZN)
3AADENOSINE-5'-DIPHOSPHATEnon-polymer427.21Chemie (ADP)
4AN-[(1S)-1-cyclopropyl-3-(methanesulfonyl)propyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamidenon-polymer439.51Chemie (X1L)
5AGLYCEROLnon-polymer92.11Chemie (GOL)
6ASODIUM IONnon-polymer23.01Chemie (NA)
7waterwater18.0203Chemie (HOH)
Sequence modifications
A: 517 - 945 (UniProt: Q14191)
PDBExternal DatabaseDetails
Met 516-initiating methionine
Gly 946-expression tag
Gly 947-expression tag
Arg 948-expression tag
Leu 949-expression tag
Glu 950-expression tag
Val 951-expression tag
Leu 952-expression tag
Phe 953-expression tag
Gln 954-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight50064.7
Non-Polymers*Number of molecules5
Total formula weight1047.2
All*Total formula weight51111.9
*Water molecules are not included.

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PDB entries from 2024-07-31

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