7G10

Crystal Structure of human FABP4 binding site mutated to that of FABP3 in complex with 1-[(4-chloro-2-phenoxyphenyl)methyl]-4-hydroxypyridin-2-one

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Fatty acid-binding protein, adipocyte	polymer	135	15060.2	1	UniProt (P15090) Pfam (PF00061) In PDB	Homo sapiens (human)	Adipocyte lipid-binding protein,ALBP,Adipocyte-type fatty acid-binding protein,A-FABP,AFABP,Fatty acid-binding protein 4
2	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
3	A	4-hydroxy-1-[(2-phenoxyphenyl)methyl]pyridin-2(1H)-one	non-polymer		293.3	1	Chemie (WMF)
4	A	DIMETHYL SULFOXIDE	non-polymer		78.1	1	Chemie (DMS)
5		water	water		18.0	145	Chemie (HOH)

Sequence modifications

A: 0 - 131 (UniProt: P15090)

PDB	External Database	Details
Gly -3	-	expression tag
Ser -2	-	expression tag
His -1	-	expression tag
Leu 23	Val 24	engineered mutation
Thr 40	Met 41	engineered mutation
Leu 51	Ile 52	engineered mutation
Thr 53	Ser 54	engineered mutation
Leu 104	Ile 105	engineered mutation
Leu 115	Val 116	engineered mutation
Leu 117	Cys 118	engineered mutation
Cys 124	Ser 125	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	15060.2
Non-Polymers*	Number of molecules	4
	Total formula weight	563.6
All*	Total formula weight	15623.8

*Water molecules are not included.