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7FYZ

Crystal Structure of human FABP4 in complex with 2-[2,3-bis[(2-chlorophenyl)methoxy]phenyl]-2-methoxyacetic acid, i.e. SMILES c1c(c(c(cc1)OCc1ccccc1Cl)OCc1c(cccc1)Cl)[C@@H](C(=O)O)OC with IC50=1.1 microM

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
Fatty acid-binding protein, adipocytepolymer13515022.21UniProt (P15090)
Pfam (PF00061)
Homo sapiens (human)Adipocyte lipid-binding protein,ALBP,Adipocyte-type fatty acid-binding protein,A-FABP,AFABP,Fatty acid-binding protein 4
2B, C
(A)
SULFATE IONnon-polymer96.12Chemie (SO4)
3D
(A)
(2R)-{2,3-bis[(2-chlorophenyl)methoxy]phenyl}(methoxy)acetic acidnon-polymer447.31Chemie (WA9)
4E
(A)
waterwater18.0181Chemie (HOH)
Sequence modifications
A: 0 - 131 (UniProt: P15090)
PDBExternal DatabaseDetails
Gly -3-expression tag
Ser -2-expression tag
His -1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight15022.2
Non-Polymers*Number of molecules3
Total formula weight639.4
All*Total formula weight15661.6
*Water molecules are not included.

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PDB entries from 2025-07-23

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