7FTM
Crystal Structure of human cyclic GMP-AMP synthase in complex with 2-[2-(4-fluoroanilino)-1,3-thiazol-4-yl]acetic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Cyclic GMP-AMP synthase | polymer | 362 | 42404.9 | 1 | UniProt (Q8N884) Pfam (PF03281) Pfam (PF20266) | Homo sapiens (human) | cGAMP synthase,cGAS,h-cGAS,2'3'-cGAMP synthase,Mab-21 domain-containing protein 1 |
| 2 | B, C (A) | [2-(4-fluoroanilino)-1,3-thiazol-4-yl]acetic acid | non-polymer | 252.3 | 2 | Chemie (YO6) | |||
| 3 | D (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | E (A) | water | water | 18.0 | 136 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42404.9 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 569.9 | |
| All* | Total formula weight | 42974.8 |
