7FS6
Structure of liver pyruvate kinase in complex with allosteric modulator 18
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E... | Pyruvate kinase PKLR | polymer | 447 | 48285.4 | 8 | UniProt (P30613) Pfam (PF00224) Pfam (PF02887) In PDB | Homo sapiens (human) | Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase |
2 | E, A, F, B, G... | 1,6-di-O-phosphono-beta-D-fructofuranose | non-polymer | 340.1 | 8 | Chemie (FBP) | |||
3 | E, A, F, B, G... | OXALATE ION | non-polymer | 88.0 | 8 | Chemie (OXL) | |||
4 | D, E, A, F, B... | MAGNESIUM ION | non-polymer | 24.3 | 8 | Chemie (MG) | |||
5 | D, E, A, F, B... | POTASSIUM ION | non-polymer | 39.1 | 8 | Chemie (K) | |||
6 | D, E, A, F, B... | (10aM)-6-{2-[4-(3,4-dihydroxybenzene-1-sulfonyl)phenyl]ethyl}-2,3,8,9-tetrahydroxy-5lambda~6~-dibenzo[c,e][1,2]thiazine-5,5(6H)-dione | non-polymer | 571.6 | 12 | Chemie (Y3Z) | |||
7 | water | water | 18.0 | 1055 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 3 - 129 (UniProt: P30613)
A, B, C, D, E, F, G, H: 231 - 543 (UniProt: P30613)
PDB | External Database | Details |
---|---|---|
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Met 1 | - | expression tag |
Glu 2 | - | expression tag |
Asp 12 | Ser 43 | conflict |
PDB | External Database | Details |
---|---|---|
Gly 130 | - | linker |
Ser 131 | - | linker |
Gly 132 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 8 |
Total formula weight | 386283.0 | |
Non-Polymers* | Number of molecules | 44 |
Total formula weight | 10791.2 | |
All* | Total formula weight | 397074.2 |