7FS0

Structure of liver pyruvate kinase in complex with allosteric modulator 8

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Pyruvate kinase PKLR	polymer	447	48285.4	8	UniProt (P30613) Pfam (PF00224) Pfam (PF02887)	Homo sapiens (human)	Pyruvate kinase 1,Pyruvate kinase isozymes L/R,R-type/L-type pyruvate kinase,Red cell/liver pyruvate kinase
2	AA, EA, I, IA, N... (E, F, A, G, B...)	1,6-di-O-phosphono-beta-D-fructofuranose	non-polymer		340.1	8	Chemie (FBP)
3	BA, FA, J, JA, O... (E, F, A, G, B...)	OXALATE ION	non-polymer		88.0	8	Chemie (OXL)
4	CA, GA, K, KA, P... (E, F, A, G, B...)	MAGNESIUM ION	non-polymer		24.3	8	Chemie (MG)
5	DA, HA, L, LA, Q... (E, F, A, G, B...)	POTASSIUM ION	non-polymer		39.1	8	Chemie (K)
6	M, MA, RA, Z (A, G, H, D)	3,4-dihydroxy-N-{2-[4-(3-hydroxybenzene-1-sulfonyl)phenyl]ethyl}benzene-1-sulfonamide	non-polymer		449.5	4	Chemie (O8X)
7	SA, TA, UA, VA, WA... (A, B, C, D, E...)	water	water		18.0	1064	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 3 - 129 (UniProt: P30613)

PDB	External Database	Details
Gly -1	-	expression tag
Ser 0	-	expression tag
Met 1	-	expression tag
Glu 2	-	expression tag
Asp 12	Ser 43	conflict

A, B, C, D, E, F, G, H: 231 - 543 (UniProt: P30613)

PDB	External Database	Details
Gly 130	-	linker
Ser 131	-	linker
Gly 132	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	386283.0
Non-Polymers*	Number of molecules	36
	Total formula weight	5730.3
All*	Total formula weight	392013.3

*Water molecules are not included.