7FIC
Reversible lysine-targeted probes reveal residence time-based kinase selectivity in vivo
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Aurora kinase A | polymer | 265 | 30718.3 | 1 | UniProt (O14965) Pfam (PF00069) In PDB | Homo sapiens (Human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,hARK1,Breast tumor-amplified kinase,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase aurora-A |
| 2 | A | 6-[(5-cyclopropyl-1~{H}-pyrazol-3-yl)amino]-2-[4-[(3-methyl-4-oxidanyl-phenyl)methyl]piperazin-1-yl]-~{N}-prop-2-ynyl-pyrimidine-4-carboxamide | non-polymer | 486.6 | 1 | Chemie (5YZ) | |||
| 3 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 4 | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A: 127 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Ala 290 | Cys 290 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 30718.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 592.9 | |
| All* | Total formula weight | 31311.2 |
