7FI7
Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | NKG2-D type II integral membrane protein | polymer | 139 | 16110.2 | 2 | UniProt (P26718) Pfam (PF00059) | Homo sapiens (Human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
| 2 | C (C) | MHC class I polypeptide-related sequence A | polymer | 275 | 31785.6 | 1 | UniProt (Q29983) Pfam (PF00129) Pfam (PF07654) | Homo sapiens (Human) | MIC-A |
| 3 | D, E, F (A, B, C) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
A, B: 80 - 216 (UniProt: P26718)
C: 2 - 275 (UniProt: Q29983)
| PDB | External Database | Details |
|---|---|---|
| Met 78 | - | initiating methionine |
| Glu 79 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 1 | - | initiating methionine |
| Met 14 | Ser 36 | engineered mutation |
| Ile 109 | Gln 131 | engineered mutation |
| Gly 121 | Gln 143 | engineered mutation |
| Trp 147 | Leu 169 | engineered mutation |
| Trp 158 | Tyr 180 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 64006.0 | |
| All* | Total formula weight | 64006.0 |
