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7FI5

Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, BNKG2-D type II integral membrane proteinpolymer13916110.22UniProt (P26718)
Pfam (PF00059)
In PDB
Homo sapiens (Human)Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor
2CMHC class I polypeptide-related sequence Apolymer27531817.51UniProt (Q29983)
Pfam (PF00129)
Pfam (PF07654)
In PDB
Homo sapiens (Human)MIC-A
3A, BGLYCEROLnon-polymer92.13Chemie (GOL)
4waterwater18.025Chemie (HOH)
Sequence modifications
A, B: 80 - 216 (UniProt: P26718)
PDBExternal DatabaseDetails
Met 78-initiating methionine
Glu 79-expression tag
C: 1 - 274 (UniProt: Q29983)
PDBExternal DatabaseDetails
Met 0-initiating methionine
His 108Gln 131engineered mutation
Trp 120Gln 143engineered mutation
Phe 127Trp 150engineered mutation
Trp 146Leu 169engineered mutation
Phe 157Tyr 180engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight64038.0
Non-Polymers*Number of molecules3
Total formula weight276.3
All*Total formula weight64314.3
*Water molecules are not included.

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PDB entries from 2024-10-09

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