7FI5
Crystal structure of human MICA mutants in complex with natural killer cell receptor NKG2D
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | NKG2-D type II integral membrane protein | polymer | 139 | 16110.2 | 2 | UniProt (P26718) Pfam (PF00059) In PDB | Homo sapiens (Human) | Killer cell lectin-like receptor subfamily K member 1,NK cell receptor D,NKG2-D-activating NK receptor |
2 | C | MHC class I polypeptide-related sequence A | polymer | 275 | 31817.5 | 1 | UniProt (Q29983) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (Human) | MIC-A |
3 | A, B | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
4 | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A, B: 80 - 216 (UniProt: P26718)
C: 1 - 274 (UniProt: Q29983)
PDB | External Database | Details |
---|---|---|
Met 78 | - | initiating methionine |
Glu 79 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 0 | - | initiating methionine |
His 108 | Gln 131 | engineered mutation |
Trp 120 | Gln 143 | engineered mutation |
Phe 127 | Trp 150 | engineered mutation |
Trp 146 | Leu 169 | engineered mutation |
Phe 157 | Tyr 180 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 64038.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 276.3 | |
All* | Total formula weight | 64314.3 |