7FHS
Crystal structure of DYRK1A in complex with RD0392
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | polymer | 361 | 42007.4 | 4 | UniProt (Q13627) Pfam (PF00069) | Homo sapiens (Human) | Dual specificity YAK1-related kinase,HP86,Protein kinase minibrain homolog,MNBH,hMNB |
| 2 | E, I, K, L (A, B, C, D) | (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one | non-polymer | 281.4 | 4 | Chemie (4VZ) | |||
| 3 | F, G, H, J, M (A, B, D) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 4 | N, O, P, Q (A, B, C, D) | water | water | 18.0 | 252 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 127 - 485 (UniProt: Q13627)
| PDB | External Database | Details |
|---|---|---|
| Gly 125 | - | expression tag |
| Ser 126 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 168029.6 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 1585.9 | |
| All* | Total formula weight | 169615.4 |
