7FGQ

Crystal structure of Thymidylate kinase with TMP and its low-resolution (SAXS) solution structure from Brugia malayi

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	dTMP kinase	polymer	252	28412.5	1	UniProt (A0A1P6BP23) Pfam (PF02223)	Brugia malayi (Filarial nematode worm)	Thymidylate Kinase
2	B (A)	THYMIDINE-5'-PHOSPHATE	non-polymer		322.2	1	Chemie (TMP)
3	C (A)	water	water		18.0	70	Chemie (HOH)

Sequence modifications

A: 1 - 213 (UniProt: A0A1P6BP23)

PDB	External Database	Details
Met -32	-	expression tag
Gly -31	-	expression tag
Ser -30	-	expression tag
Ser -29	-	expression tag
His -28	-	expression tag
His -27	-	expression tag
His -26	-	expression tag
His -25	-	expression tag
His -24	-	expression tag
His -23	-	expression tag
Ser -22	-	expression tag
Ser -21	-	expression tag
Gly -20	-	expression tag
Leu -19	-	expression tag
Val -18	-	expression tag
Pro -17	-	expression tag
Arg -16	-	expression tag
Gly -15	-	expression tag
Ser -14	-	expression tag
His -13	-	expression tag
Met -12	-	expression tag
Ala -11	-	expression tag
Ser -10	-	expression tag
Met -9	-	expression tag
Thr -8	-	expression tag
Gly -7	-	expression tag
Gly -6	-	expression tag
Gln -5	-	expression tag
Gln -4	-	expression tag
Met -3	-	expression tag
Gly -2	-	expression tag
Arg -1	-	expression tag
Gly 0	-	expression tag
His 214	-	expression tag
His 215	-	expression tag
His 216	-	expression tag
His 217	-	expression tag
His 218	-	expression tag
His 219	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	28412.5
Non-Polymers*	Number of molecules	1
	Total formula weight	322.2
All*	Total formula weight	28734.7

*Water molecules are not included.