7FD9
Thermostabilised full length human mGluR5-5M with orthosteric antagonist, LY341495
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Metabotropic glutamate receptor 5 | polymer | 862 | 96954.0 | 2 | UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) | Homo sapiens (Human) | mGluR5 |
| 2 | C, E (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 3 | D, F (A, B) | 2-[(1S,2S)-2-carboxycyclopropyl]-3-(9H-xanthen-9-yl)-D-alanine | non-polymer | 353.4 | 2 | Chemie (Z99) PubChem (44300270) PubChem (44348804) PubChem (57824323) PubChem (4364840) PubChem (69351741) PubChem (68198047) PubChem (89651894) PubChem (6604829) PubChem (9819927) PubChem (9975366) PubChem (10618042) PubChem (10713043) PubChem (10807972) PubChem (138113521) PubChem (156758060) PubChem (163320174) PubChem (169545577) PubChem (171041419) |
Sequence modifications
A, B: 21 - 856 (UniProt: P41594)
| PDB | External Database | Details |
|---|---|---|
| Asp -5 | - | expression tag |
| Tyr -4 | - | expression tag |
| Lys -3 | - | expression tag |
| Asp -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Asp 0 | - | expression tag |
| Asp 1 | - | expression tag |
| Lys 2 | - | expression tag |
| His 3 | - | expression tag |
| His 4 | - | expression tag |
| His 5 | - | expression tag |
| His 6 | - | expression tag |
| His 7 | - | expression tag |
| His 8 | - | expression tag |
| His 9 | - | expression tag |
| His 10 | - | expression tag |
| His 11 | - | expression tag |
| His 12 | - | expression tag |
| Leu 13 | - | expression tag |
| Glu 14 | - | expression tag |
| Val 15 | - | expression tag |
| Leu 16 | - | expression tag |
| Phe 17 | - | expression tag |
| Gln 18 | - | expression tag |
| Gly 19 | - | expression tag |
| Pro 20 | - | expression tag |
| Leu 350 | His 350 | engineered mutation |
| Ala 445 | Asn 445 | engineered mutation |
| Ala 742 | Thr 742 | engineered mutation |
| Ala 753 | Ser 753 | engineered mutation |
| Ala 777 | Thr 777 | engineered mutation |
| Ala 799 | Ile 799 | engineered mutation |
| Leu 813 | Ala 813 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 193908.0 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1149.2 | |
| All* | Total formula weight | 195057.1 |
