7FD8

Thermostabilised full length human mGluR5-5M bound with L-quisqualic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Metabotropic glutamate receptor 5	polymer	862	96954.0	2	UniProt (P41594) Pfam (PF01094) Pfam (PF07562) Pfam (PF00003) In PDB	Homo sapiens (Human)	mGluR5
2	A, B	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
3	A, B	(S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID	non-polymer		189.1	2	Chemie (QUS)
4	A, B	CHOLESTEROL HEMISUCCINATE	non-polymer		486.7	2	Chemie (Y01)

Sequence modifications

A, B: 21 - 856 (UniProt: P41594)

PDB	External Database	Details
Asp -5	-	expression tag
Tyr -4	-	expression tag
Lys -3	-	expression tag
Asp -2	-	expression tag
Asp -1	-	expression tag
Asp 0	-	expression tag
Asp 1	-	expression tag
Lys 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
Leu 13	-	expression tag
Glu 14	-	expression tag
Val 15	-	expression tag
Leu 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Pro 20	-	expression tag
Leu 350	His 350	engineered mutation
Ala 445	Asn 445	engineered mutation
Ala 742	Thr 742	engineered mutation
Ala 753	Ser 753	engineered mutation
Ala 777	Thr 777	engineered mutation
Ala 799	Ile 799	engineered mutation
Leu 813	Ala 813	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	193908.0
Non-Polymers*	Number of molecules	6
	Total formula weight	1794.1
All*	Total formula weight	195702.1

*Water molecules are not included.