7F9V
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Halofuginone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prolyl-tRNA synthetase (ProRS) | polymer | 500 | 57937.3 | 2 | UniProt (A0A7J6JUK2) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Toxoplasma gondii | |
| 2 | C, Q (A, B) | 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide | non-polymer | 486.5 | 2 | Chemie (1TI) | |||
| 3 | D, R (A, B) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 4 | E (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | F (A) | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 1 | Chemie (BME) | |||
| 6 | AA, BA, G, J, M... (B, A) | BROMIDE ION | non-polymer | 79.9 | 6 | Chemie (BR) | |||
| 7 | H, I, K, L, P... (A, B) | IODIDE ION | non-polymer | 126.9 | 10 | Chemie (IOD) | |||
| 8 | N, O, Y (A, B) | FLUORIDE ION | non-polymer | 19.0 | 3 | Chemie (F) | |||
| 9 | S (B) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 10 | CA, DA (A, B) | water | water | 18.0 | 567 | Chemie (HOH) |
Sequence modifications
A, B: 334 - 830 (UniProt: A0A7J6JUK2)
| PDB | External Database | Details |
|---|---|---|
| Gly 331 | - | expression tag |
| Ala 332 | - | expression tag |
| Met 333 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115874.5 | |
| Non-Polymers* | Number of molecules | 26 |
| Total formula weight | 3973.4 | |
| All* | Total formula weight | 119847.9 |
