7F9U
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor T35 and Halofuginone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Prolyl-tRNA synthetase (ProRS) | polymer | 500 | 57937.3 | 4 | UniProt (A0A7J6JUK2) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Toxoplasma gondii | |
| 2 | E, M, T, X (A, B, C, D) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 4 | Chemie (HFG) | |||
| 3 | F, N, U, Y (A, B, C, D) | 4-[(3S)-3-cyano-3-(1-methylcyclopropyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide | non-polymer | 486.5 | 4 | Chemie (1TI) | |||
| 4 | G, O, Z (A, B, D) | BROMIDE ION | non-polymer | 79.9 | 3 | Chemie (BR) | |||
| 5 | H, I, P (A, B) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | J, K, L, Q, R... (A, B, C) | CHLORIDE ION | non-polymer | 35.5 | 8 | Chemie (CL) | |||
| 7 | AA, BA, CA, DA (A, B, C, D) | water | water | 18.0 | 50 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 334 - 830 (UniProt: A0A7J6JUK2)
| PDB | External Database | Details |
|---|---|---|
| Gly 331 | - | expression tag |
| Ala 332 | - | expression tag |
| Met 333 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 231749.0 | |
| Non-Polymers* | Number of molecules | 22 |
| Total formula weight | 4248.5 | |
| All* | Total formula weight | 235997.5 |
