7F9T
Toxoplasma gondii Prolyl-tRNA Synthetase (TgPRS) in Complex with inhibitor L97 and Halofuginone
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Prolyl-tRNA synthetase (ProRS) | polymer | 500 | 57937.3 | 2 | UniProt (A0A7J6JUK2) Pfam (PF00587) Pfam (PF03129) Pfam (PF09180) | Toxoplasma gondii | |
| 2 | C, R (A, B) | 4-[(3S)-3-cyclopropyl-3-(hydroxymethyl)-2-oxidanylidene-pyrrolidin-1-yl]-N-[[3-fluoranyl-5-(1-methylpyrazol-4-yl)phenyl]methyl]-6-methyl-pyridine-2-carboxamide | non-polymer | 477.5 | 2 | Chemie (1XK) | |||
| 3 | D, S (A, B) | 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one | non-polymer | 414.7 | 2 | Chemie (HFG) | |||
| 4 | E (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 5 | F, T (A, B) | OXAMIC ACID | non-polymer | 89.0 | 2 | Chemie (OXM) | |||
| 6 | CA, G, H, I, Q... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 7 | AA, BA, J, K, L... (B, A) | FORMIC ACID | non-polymer | 46.0 | 13 | Chemie (FMT) | |||
| 8 | V (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 9 | DA, EA (A, B) | water | water | 18.0 | 773 | Chemie (HOH) |
Sequence modifications
A, B: 334 - 830 (UniProt: A0A7J6JUK2)
| PDB | External Database | Details |
|---|---|---|
| Gly 331 | - | expression tag |
| Ala 332 | - | expression tag |
| Met 333 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 115874.5 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 3187.5 | |
| All* | Total formula weight | 119062.1 |
