7F8Y

Crystal structure of the cholecystokinin receptor CCKAR in complex with devazepide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	fusion protein of Cholecystokinin receptor type A and Endolysin	polymer	534	60450.4	1	UniProt (P32238) UniProt (P00720) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (Human)	CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R,Lysis protein,Lysozyme,Muramidase
2	A	N-[(3S)-1-methyl-2-oxidanylidene-5-phenyl-3H-1,4-benzodiazepin-3-yl]-1H-indole-2-carboxamide	non-polymer		408.5	1	Chemie (1OZ)

Sequence modifications

A: 37 - 240 (UniProt: P32238)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Asp 2	-	expression tag
Val 3	-	expression tag
Val 4	-	expression tag
Asp 5	-	expression tag
Ser 6	-	expression tag
Leu 7	-	expression tag
Leu 8	-	expression tag
Val 9	-	expression tag
Asn 10	-	expression tag
Gly 11	-	expression tag
Ser 12	-	expression tag
Asn 13	-	expression tag
Ile 14	-	expression tag
Thr 15	-	expression tag
Pro 16	-	expression tag
Pro 17	-	expression tag
Cys 18	-	expression tag
Glu 19	-	expression tag
Leu 20	-	expression tag
Gly 21	-	expression tag
Leu 22	-	expression tag
Glu 23	-	expression tag
Asn 24	-	expression tag
Glu 25	-	expression tag
Thr 26	-	expression tag
Leu 27	-	expression tag
Phe 28	-	expression tag
Cys 29	-	expression tag
Leu 30	-	expression tag
Asp 31	-	expression tag
Gln 32	-	expression tag
Pro 33	-	expression tag
Arg 34	-	expression tag
Pro 35	-	expression tag
Ser 36	-	expression tag
Asn 87	Asp 87	engineered mutation
Trp 130	Phe 130	engineered mutation

A: 1241 - 1400 (UniProt: P00720)

PDB	External Database	Details
Gly 1251	Arg 12	engineered mutation
Thr 1293	Cys 54	engineered mutation
Ala 1336	Cys 97	engineered mutation
Arg 1376	Ile 137	engineered mutation

A: 302 - 406 (UniProt: P32238)

PDB	External Database	Details
Glu 407	-	expression tag
Phe 408	-	expression tag
Leu 409	-	expression tag
Glu 410	-	expression tag
Val 411	-	expression tag
Leu 412	-	expression tag
Phe 413	-	expression tag
Gln 414	-	expression tag
Gly 415	-	expression tag
Pro 416	-	expression tag
His 417	-	expression tag
His 418	-	expression tag
His 419	-	expression tag
His 420	-	expression tag
His 421	-	expression tag
His 422	-	expression tag
His 423	-	expression tag
His 424	-	expression tag
His 425	-	expression tag
His 426	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	60450.4
Non-Polymers*	Number of molecules	1
	Total formula weight	408.5
All*	Total formula weight	60858.8

*Water molecules are not included.