7F8X

Crystal structure of the cholecystokinin receptor CCKAR in complex with NN9056

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Cholecystokinin receptor type A,Endolysin	polymer	534	60451.4	1	UniProt (P32238) UniProt (P00720) Pfam (PF09193) Pfam (PF00001) Pfam (PF00959) In PDB	Homo sapiens (human)	CCK-A receptor,CCK-AR,Cholecystokinin-1 receptor,CCK1-R,Lysis protein,Lysozyme,Muramidase
2	C	ASP-SMF-NLE-GLY-TRP-NLE-OEM-MEA-NH2 (NN9056)	polymer	9	1132.3	1		synthetic construct

Sequence modifications

A: 2 - 240 (UniProt: P32238)

PDB	External Database	Details
Asp -8	-	expression tag
Tyr -7	-	expression tag
Lys -6	-	expression tag
Asp -5	-	expression tag
Asp -4	-	expression tag
Asp -3	-	expression tag
Asp -2	-	expression tag
Gly -1	-	expression tag
Ala 0	-	expression tag
Pro 1	-	expression tag
Trp 130	Phe 130	engineered mutation

A: 241 - 535 (UniProt: P00720)

PDB	External Database	Details
Gly 251	Arg 12	engineered mutation
Thr 428	Cys 54	engineered mutation
Ala 471	Cys 97	engineered mutation
Arg 511	Ile 137	engineered mutation

A: 536 - 640 (UniProt: P32238)

PDB	External Database	Details
Glu 641	-	expression tag
Phe 642	-	expression tag
Leu 643	-	expression tag
Glu 644	-	expression tag
Val 645	-	expression tag
Leu 646	-	expression tag
Phe 647	-	expression tag
Gln 648	-	expression tag
Gly 649	-	expression tag
Pro 650	-	expression tag
His 651	-	expression tag
His 652	-	expression tag
His 653	-	expression tag
His 654	-	expression tag
His 655	-	expression tag
His 656	-	expression tag
His 657	-	expression tag
His 658	-	expression tag
His 659	-	expression tag
His 660	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	61583.6
All*	Total formula weight	61583.6

*Water molecules are not included.