7F8W
Cryo-EM structure of the cholecystokinin receptor CCKBR in complex with gastrin-17 and Gq
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Guanine nucleotide-binding protein G(q) subunit alpha | polymer | 353 | 41353.1 | 1 | UniProt (P50148) Pfam (PF00503) In PDB | Homo sapiens (Human) | Guanine nucleotide-binding protein alpha-q |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 351 | 38744.4 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | D | scFv16 | polymer | 268 | 28621.1 | 1 | Homo sapiens | ||
5 | E | Gastrin-17 | polymer | 17 | 2098.2 | 1 | Pfam (PF00918) UniProt (by SIFTS) (P01350) In PDB | Homo sapiens | |
6 | R | Gastrin/cholecystokinin type B receptor | polymer | 465 | 50524.9 | 1 | UniProt (P32239) Pfam (PF00001) In PDB | Homo sapiens (Human) | CCK-B receptor,CCK-BR,Cholecystokinin-2 receptor,CCK2-R |
Sequence modifications
A: 23 - 353 (UniProt: P50148)
B: 2 - 340 (UniProt: P62873)
R: 2 - 418 (UniProt: P32239)
PDB | External Database | Details |
---|---|---|
Met 1 | - | initiating methionine |
Gly 2 | - | expression tag |
Cys 3 | - | expression tag |
Thr 4 | - | expression tag |
Leu 5 | - | expression tag |
Ser 6 | - | expression tag |
Ala 7 | - | expression tag |
Glu 8 | - | expression tag |
Asp 9 | - | expression tag |
Lys 10 | - | expression tag |
Ala 11 | - | expression tag |
Ala 12 | - | expression tag |
Val 13 | - | expression tag |
Glu 14 | - | expression tag |
Arg 15 | - | expression tag |
Ser 16 | - | expression tag |
Lys 17 | - | expression tag |
Met 18 | - | expression tag |
Ile 19 | - | expression tag |
Asp 20 | - | expression tag |
Arg 21 | - | expression tag |
Asn 22 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -10 | - | expression tag |
His -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
Gly -3 | - | expression tag |
Ser -2 | - | expression tag |
Leu -1 | - | expression tag |
Leu 0 | - | expression tag |
Gln 1 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Asp -8 | - | expression tag |
Tyr -7 | - | expression tag |
Lys -6 | - | expression tag |
Asp -5 | - | expression tag |
Asp -4 | - | expression tag |
Asp -3 | - | expression tag |
Asp -2 | - | expression tag |
Gly -1 | - | expression tag |
Ala 0 | - | expression tag |
Pro 1 | - | expression tag |
Glu 419 | - | expression tag |
Phe 420 | - | expression tag |
Leu 421 | - | expression tag |
Glu 422 | - | expression tag |
Val 423 | - | expression tag |
Leu 424 | - | expression tag |
Phe 425 | - | expression tag |
Gln 426 | - | expression tag |
Gly 427 | - | expression tag |
Pro 428 | - | expression tag |
Trp 429 | - | expression tag |
Ser 430 | - | expression tag |
His 431 | - | expression tag |
Pro 432 | - | expression tag |
Gln 433 | - | expression tag |
Phe 434 | - | expression tag |
Glu 435 | - | expression tag |
Lys 436 | - | expression tag |
Gly 437 | - | expression tag |
Gly 438 | - | expression tag |
Gly 439 | - | expression tag |
Ser 440 | - | expression tag |
Gly 441 | - | expression tag |
Gly 442 | - | expression tag |
Gly 443 | - | expression tag |
Ser 444 | - | expression tag |
Gly 445 | - | expression tag |
Gly 446 | - | expression tag |
Ser 447 | - | expression tag |
Ala 448 | - | expression tag |
Trp 449 | - | expression tag |
Ser 450 | - | expression tag |
His 451 | - | expression tag |
Pro 452 | - | expression tag |
Gln 453 | - | expression tag |
Phe 454 | - | expression tag |
Glu 455 | - | expression tag |
Lys 456 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 169202.9 | |
All* | Total formula weight | 169202.9 |