7F8P
Crystal structure of the Mycobacterium tuberculosis L,D-transpeptidase-2 (LdtMt2) with new carbapenem drug T203
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | L,D-transpeptidase 2 | polymer | 370 | 39532.0 | 2 | UniProt (I6Y9J2) Pfam (PF17964) Pfam (PF03734) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | LDT 2,Ldt(Mt2) |
| 2 | C (A) | (2R,3R)-3-methyl-4-(2-oxidanylidene-2-propan-2-yloxy-ethyl)sulfanyl-2-[(2R)-3-oxidanyl-1-oxidanylidene-butan-2-yl]-2,3-dihydro-1H-pyrrole-5-carboxylic acid | non-polymer | 345.4 | 1 | Chemie (59I) | |||
| 3 | D, F, H (A, B) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 4 | E (A) | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 5 | G (A) | (4R,5S,6S)-6-((R)-1-hydroxyethyl)-3-((2-isopropoxy-2-oxoethyl)thio)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid | non-polymer | 343.4 | 1 | Chemie (56X) | |||
| 6 | I, J (A, B) | water | water | 18.0 | 854 | Chemie (HOH) |
Sequence modifications
A, B: 42 - 408 (UniProt: I6Y9J2)
| PDB | External Database | Details |
|---|---|---|
| Gly 39 | - | expression tag |
| His 40 | - | expression tag |
| Met 41 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 79064.0 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1112.2 | |
| All* | Total formula weight | 80176.2 |
